当研究室は日本神経病理学会の認定施設であり、豊富な剖検組織の蓄積があります。これらは、京都大学神経内科およびその関連施設で亡くなられ、剖検された方々からの貴重な献体によるものであり、私たちの研究室の歴代担当者によって神経病理診断され、パラフィンブロックは厳重に保管されています。これらの検体を用い、私たちは、筋萎縮性側索硬化症(ALS)やパーキンソン病およびその類縁疾患、血管性認知症とアルツハイマー病の発症機構の解明に取り組んでいます。総数は376例で、内訳は以下の通りです。

　近年、神経変性疾患の多くは異常なタンパク質の蓄積が病態の鍵であることが判明し、神経病理学の果たす役割は
以前に増して注目されています。研究室の前々責任者である、和歌山県立医科大学神経内科 伊東秀文教授は広島大学や徳島大学、関西医科大学との共同研究で家族性ALSの新規遺伝子オプチニューリン(Optineurin; OPTN)を世界で最初に発見し、神経病理像を報告しました（Nature 2010)。また、研究室の前責任者である滋賀医科大学神経内科 漆谷真教授の元、家族性ALSの原因と一つである変異SOD1蛋白質がシナプス分泌蛋白質とともに細胞外に分泌されミクログリアの活性化や運動ニューロン死をきたすことを突き止め、ワクチン・抗体療法の有用性を報告しました(Nat Neurosci 2006, PNAS 2007)。
現在でも、和歌山県立医科大学神経内科、滋賀医科大学神経内科とは緊密な共同研究体制を構築しており、和歌山県立医科大学神経内科との共同研究では、中條西村症候群の筋病理像の報告（Neuropathol Appl Neurobiol.2020）を、滋賀医大との共同研究では、ALSの動物モデルに対する抗体治療の効果を報告しました（Sci Rep. 2018）。
当研究室は神経病理学、機能画像、オリゴデンドログリアなど研究室の研究指導者も充実してきており、多面的なアプローチも可能になっています。

我々の研究グループでは、培養細胞、マウス脳、ヒト剖検脳など様々な研究対象を用いて、脳梗塞、血管性認知症、アルツハイマー病などの神経疾患の研究に取り組んでいます。

神経疾患を考える上で、神経細胞のみではなく、神経系・グリア系・血管系・免疫系を含めた神経グリア血管単位（Neurovascular unit、NVU）として、脳を包括的にとらえる重要性が提唱されています。

実際に、脳血管障害、認知症、神経変性疾患、神経免疫疾患を含む多くの神経疾患において、神経グリア血管単位の機能不全が、病態の発症や進行に密接に影響していることが多面的な観点から示されつつあります（CNS Neurol Disord Drug Targets 2013、Nat Med. 2016）。

神経グリア血管単位を構成する細胞の中で、我々はグリア細胞の１つであるオリゴデンドロサイトとその前駆細胞 (Oligodendrocyte precursor cell、OPC）に注目して研究を行っています。OPCはオリゴデンドロサイトの供給源であるということだけでなく、高い増殖能と遊走能を持ち、脳内外に存在する他の細胞種と様々な相互連携をしていることが報告されてきています (Clin Exp Neuroimmunol. 2017)。

たとえば、OPCの一部は血管周囲に存在し、血液脳関門の形成や障害後の機能制御において重要な役割を果たしうること（J Clin Invest. 2013、PLoS One 2014）、血管周囲領域においてOPCとペリサイトが近接して存在し、相互に作用することを報告してきました。（Neurosci Lett 2015、Stem Cells 2018）。また、脳梗塞後の皮質虚血領域において、血管周囲のOPCが増加し血管新生を促進することも見出しました (J Am Heart Assoc. 2019)。さらに、OPCの多様性の一つとして、OPCの遺伝子発現パターンや機能特性には性差があることを報告しました (Stem Cell Res. 2020)。

今後は、各神経疾患において、OPCがその他の細胞種とどのように相互作用し病態に関与するのかを解明することにより、新しい診断・治療アプローチの創出につなげていきたいと考えています。

　パーキンソン病やアルツハイマー病をはじめとする神経変性疾患を対象として、MRIや核医学などの画像技術を用いて病態解明につなげる研究を展開しています。具体的には、脳領域間の解剖学的、あるいは機能的結合を、生体内で可視化するMRIの解析手法や、アミロイドβやドパミン神経を可視化する核医学検査などを組み合わせることで、病理学的変化の空間的広がりや、これに基づく機能異常の側面から病態解明を目指しています。さらに、世界的にも貴重な7テスラMRIを用いた研究で、従来の画像解析では明らかにできなかった微細な構造異常を特定することを目指しています。このような最先端の解析手法を用いて、生体内での知見をもとに神経変性疾患の克服につながる、より詳細な病態解明を目指しています。

　京都府立医科大学神経内科免疫グループと同一グループとして神経免疫疾患の臨床研究から基礎研究まで活動しています。 多発性硬化症（MS）を標的とする研究は臨床神経学のみならず、T細胞の抗原認識など免疫学にも大きな貢献をしています。多発性硬化症とその実験動物モデルの研究によって得られています。私達も免疫学の教科書に載るような成果を夢みています。 免疫系は免疫細胞と免疫関連分子が免疫ネットワークを形成し、お互いに制御しながら様々なバランスの中で生体防御をしています。MSはT細胞病、視神経脊髄炎(NMO)は抗体病とされていますが、免疫病態は実はより複雑です。神経免疫疾患の病態を免疫ネットワークの破綻として解析しています。 てんかん・運動異常生理学講座、神経生理学研究グループと自己免疫機序によるてんかんに関する共同研究をしています。病因抗体の同定できなかった場合の病態バイオマーカーを探索することが目的です。 同志社大学生命医科学部池川雅哉教授とプロテオミクスを用いた神経免疫疾患の共同研究しています。過去に私たちは視神経脊髄炎と多発性硬化症の蛋白プロファイルが相違すること(Annals of Neurology, 2012)を明らかにしています。

神経疾患の疑問について様々な角度から検証が可能です。
当研究室に興味を持たれた方はご連絡下さい。

第1,2研究室　責任者
眞木崇州

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神経病理学部門2015-2021年英文原著リスト

【2021年】

1.Inoue Y, Ayaki T, Ishimoto T, Yamakado H, Maki T, Matsuzawa S, Sawamoto N, Takahashi R. The stimulator of interferon genes (STING) pathway is upregulated in striatal astrocytes of patients with multiple system atrophy. Neurosci Lett. 2021 Jul 13;757:135972. doi: 10.1016/j.neulet.2021.135972. Epub 2021 May 24. PMID: 34033888.

 

2.Suzuki M, Fushimi Y, Okada T, Hinoda T, Nakamoto R, Arakawa Y, Sawamoto N, Togashi K, Nakamoto Y. Quantitative and qualitative evaluation of sequential PET/MRI using a newly developed mobile PET system for brain imaging. Jpn J Radiol. 2021 Jul;39(7):669-680. doi: 10.1007/s11604-021-01105-9. Epub 2021 Feb 28. PMID: 33641056.

 

3.Wicaksono KP, Fushimi Y, Nakajima S, Yokota Y, Oshima S, Otani S, Sakurama A, Shima A, Sawamoto N, Okada T, Nakamoto Y. Two-Minute Quantitative Susceptibility Mapping From Three-Dimensional Echo-Planar Imaging: Accuracy, Reliability, and Detection Performance in Patients With Cerebral Microbleeds. Invest Radiol. 2021 Feb 1;56(2):69-77. doi: 10.1097/RLI.0000000000000708. PMID: 32649332.

 

4.Shima A, Maki T, Mimura N, Yamashita H, Emoto N, Yoshifuji H, Takahashi R. A case of reversible cerebral vasoconstriction syndrome associated with anti-phospholipid antibody syndrome and systemic lupus erythematosus. eNeurologicalSci. 2021 Jun 16;24:100351. doi: 10.1016/j.ensci.2021.100351. PMID: 34258413; PMCID: PMC8253938.

 

5.Kondo T, Banno H, Okunomiya T, Amino Y, Endo K, Nakakura A, Uozumi R, Kinoshita A, Tada H, Morita S, Ishikawa H, Shindo A, Yasuda K, Taruno Y, Maki T, Suehiro T, Mori K, Ikeda M, Fujita K, Izumi Y, Kanemaru K, Ishii K, Shigenobu K, Kutoku Y, Sunada Y, Kawakatsu S, Shiota S, Watanabe T, Uchikawa O, Takahashi R, Tomimoto H, Inoue H. Repurposing bromocriptine for Aβ metabolism in Alzheimer’s disease (REBRAnD) study: randomised placebo-controlled double-blind comparative trial and open-label extension trial to investigate the safety and efficacy of bromocriptine in Alzheimer’s disease with presenilin 1 (PSEN1) mutations. BMJ Open. 2021 Jun 30;11(6):e051343. doi: 10.1136/bmjopen-2021-051343. PMID: 34193504; PMCID: PMC8246358.

 

6.Wada T, Shima A, Kuzuya A, Maki T, Yamashita H, Takahashi R. Dynamic alteration of internal carotid artery related to granuloma in a case of Tolosa-Hunt syndrome. Acta Neurol Belg. 2021 Jun 28. doi: 10.1007/s13760-021-01737-8. Epub ahead of print. PMID: 34184194.

 

7.Yang T, Yoshida K, Maki T, Fushimi Y, Yamada K, Okawa M, Yamamoto Y, Takayama N, Suzuki K, Miyamoto S. Prevalence and site of predilection of carotid webs focusing on symptomatic and asymptomatic Japanese patients. J Neurosurg. 2021 Mar 5:1-7. doi: 10.3171/2020.8.JNS201727. Epub ahead of print. PMID: 33668027.

 

8.Koyama T, Kuriyama N, Suzuki Y, Saito S, Tanaka R, Iwao M, Tanaka M, Maki T, Itoh H, Ihara M, Shindo T, Uehara R. Mid-regional pro-adrenomedullin is a novel biomarker for arterial stiffness as the criterion for vascular failure in a cross-sectional study. Sci Rep. 2021 Jan 11;11(1):305. doi: 10.1038/s41598-020-79525-2. PMID: 33431996; PMCID: PMC7801498.

 

9.Shindo A, Takase H, Hamanaka G, Chung KK, Mandeville ET, Egawa N, Maki T, Borlongan M, Takahashi R, Lok J, Tomimoto H, Lo EH, Arai K. Biphasic roles of pentraxin 3 in cerebrovascular function after white matter stroke. CNS Neurosci Ther. 2021 Jan;27(1):60-70. doi: 10.1111/cns.13510. Epub 2020 Dec 11. PMID: 33314664; PMCID: PMC7804900.

 

10.Nguyen QL, Okuno N, Hamashima T, Dang ST, Fujikawa M, Ishii Y, Enomoto A, Maki T, Nguyen HN, Nguyen VT, Fujimori T, Mori H, Andrae J, Betsholtz C, Takao K, Yamamoto S, Sasahara M. Vascular PDGFR-alpha protects against BBB dysfunction after stroke in mice. Angiogenesis. 2021 Feb;24(1):35-46. doi: 10.1007/s10456-020-09742-w. Epub 2020 Sep 12. PMID: 32918673.

 

11.Ono E, Ishii A, Higashi Y, Koita N, Ayaki T, Tanigaki K, Takayanagi S, Kondo N, Sakai K, Endo S, Yokoi H, Matsubara T, Minamiguchi S, Nishino I, Takahashi R, Yanagita M. Monoclonal gammopathy of renal significance (MGRS)-related AL amyloidosis complicated by amyloid myopathy: a case report. BMC Nephrol. 2021 Feb 27;22(1):74. doi: 10.1186/s12882-021-02272-7. PMID: 33639890; PMCID: PMC7916314.

 

【2020年】

1.Oshima S, Fushimi Y, Okada T, Nakajima S, Yokota Y, Shima A, Grinstead J, Ahn S, Sawamoto N, Takahashi R, Nakamoto Y. Neuromelanin-Sensitive Magnetic Resonance Imaging Using DANTE Pulse. Mov Disord. 2021 Apr;36(4):874-882. doi: 10.1002/mds.28417. Epub 2020 Dec 14. PMID: 33314293; PMCID: PMC8247273.

 

2.Yamamoto J, Omura T, Kasamo S, Yamamoto S, Kawata M, Yonezawa A, Taruno Y, Endo H, Aizawa H, Sawamoto N, Matsubara K, Takahashi R, Tasaki Y. Impact of the catechol-O-methyltransferase Val158Met polymorphism on the pharmacokinetics of L-dopa and its metabolite 3-O-methyldopa in combination with entacapone. J Neural Transm (Vienna). 2021 Jan;128(1):27-36. doi: 10.1007/s00702-020-02267-y. Epub 2020 Nov 2. PMID: 33136226.

 

3.Inoue T, Kobayashi K, Matsumoto R, Inouchi M, Togo M, Togawa J, Usami K, Shimotake A, Matsuhashi M, Kikuchi T, Yoshida K, Kawawaki H, Sawamoto N, Kunieda T, Miyamoto S, Takahashi R, Ikeda A. Engagement of cortico-cortical and cortico-subcortical networks in a patient with epileptic spasms: An integrated neurophysiological study. Clin Neurophysiol. 2020 Sep;131(9):2255-2264. doi: 10.1016/j.clinph.2020.04.167. Epub 2020 May 29. PMID: 32736326.

 

4.Togo M, Inouchi M, Matsumoto R, Sawamoto N, Ikeda A, Takahashi R. [A case of refractory generalized atonic seizure and hemifacial spasm with the possible causative pontocerebellar lesion]. Rinsho Shinkeigaku. 2020 May 26;60(5):362-366. Japanese. doi: 10.5692/clinicalneurol.cn-001368. Epub 2020 Apr 18. PMID: 32307394.

 

5.Oshima S, Fushimi Y, Okada T, Takakura K, Liu C, Yokota Y, Arakawa Y, Sawamoto N, Miyamoto S, Togashi K. Brain MRI with Quantitative Susceptibility Mapping: Relationship to CT Attenuation Values. Radiology. 2020 Mar;294(3):600-609. doi: 10.1148/radiol.2019182934. Epub 2020 Jan 7. PMID: 31909699.

 

6.Kaji S, Maki T, Ueda J, Ishimoto T, Inoue Y, Yasuda K, Sawamura M, Hikawa R, Ayaki T, Yamakado H, Takahashi R. BCAS1-positive immature oligodendrocytes are affected by the α-synuclein-induced pathology of multiple system atrophy. Acta Neuropathol Commun. 2020 Jul 29;8(1):120. doi: 10.1186/s40478-020-00997-4. PMID: 32727582; PMCID: PMC7391509.

 

7.Yasuda K, Maki T, Kinoshita H, Kaji S, Toyokawa M, Nishigori R, Kinoshita Y, Ono Y, Kinoshita A, Takahashi R. Sex-specific differences in transcriptomic profiles and cellular characteristics of oligodendrocyte precursor cells. Stem Cell Res. 2020 Jul;46:101866. doi: 10.1016/j.scr.2020.101866. Epub 2020 Jun 7. PMID: 32563975.

 

8.Uemura MT, Maki T, Ihara M, Lee VMY, Trojanowski JQ. Brain Microvascular Pericytes in Vascular Cognitive Impairment and Dementia. Front Aging Neurosci. 2020 Apr 14;12:80. doi: 10.3389/fnagi.2020.00080. PMID: 32317958; PMCID: PMC7171590.

 

9.Kaji S, Maki T, Ishimoto T, Yamakado H, Takahashi R. Insights into the pathogenesis of multiple system atrophy: focus on glial cytoplasmic inclusions. Transl Neurodegener. 2020 Feb 17;9:7. doi: 10.1186/s40035-020-0185-5. PMID: 32095235; PMCID: PMC7025408.

 

10.Oka Y, Saiki H, Hashimoto Y, Terada Y, Nakamura T, Ayaki T, Orimo S, Matsumoto S. Japanese Familial Cases of Frontotemporal Dementia and Parkinsonism with N279K Tau Gene Mutation. Mov Disord Clin Pract. 2020 Nov 3;8(1):126-132. doi: 10.1002/mdc3.13100. PMID: 33426168; PMCID: PMC7780954.

 

11.Kurashige T, Kuramochi M, Ohsawa R, Yamashita Y, Shioi G, Morino H, Kamada M, Ayaki T, Ito H, Sotomaru Y, Maruyama H, Kawakami H. Optineurin defects cause TDP43-pathology with autophagic vacuolar formation. Neurobiol Dis. 2021 Jan;148:105215. doi: 10.1016/j.nbd.2020.105215. Epub 2020 Dec 6. PMID: 33296728.

 

12.Kawamoto Y, Ayaki T, Urushitani M, Ito H, Takahashi R. Accumulation of HAX-1 and PARL in brainstem- and cortical-type Lewy bodies in Parkinson’s disease and dementia with Lewy bodies. J Neurol Sci. 2020 Aug 15;415:116928. doi: 10.1016/j.jns.2020.116928. Epub 2020 May 20. PMID: 32470650.

 

13.Nakayama Y, Tsuji K, Ayaki T, Mori M, Tokunaga F, Ito H. Linear Polyubiquitin Chain Modification of TDP-43-Positive Neuronal Cytoplasmic Inclusions in Amyotrophic Lateral Sclerosis. J Neuropathol Exp Neurol. 2020 Mar 1;79(3):256-265. doi: 10.1093/jnen/nlz135. PMID: 31951008.

 

14.Taguchi T, Ikuno M, Hondo M, Parajuli LK, Taguchi K, Ueda J, Sawamura M, Okuda S, Nakanishi E, Hara J, Uemura N, Hatanaka Y, Ayaki T, Matsuzawa S, Tanaka M, El-Agnaf OMA, Koike M, Yanagisawa M, Uemura MT, Yamakado H, Takahashi R. α-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson’s disease model. Brain. 2020 Jan 1;143(1):249-265. doi: 10.1093/brain/awz380. Erratum in: Brain. 2020 Mar 1;143(3):e24. PMID: 31816026.

 

【2019年】

1.Yasuda K, Maki T, Kimura K, Ayaki T, Sawamoto N, Murase N, Ohtani R, Takahashi R, Nakamura M. Two cases of delayed perforating artery infarction adjacent to intracranial hemorrhage. eNeurologicalSci. 2019 Sep 12;17:100209. doi: 10.1016/j.ensci.2019.100209. PMID: 31650047; PMCID: PMC6804496.

 

2.Minamiyama S, Ueda S, Nakashima R, Yamakado H, Sakato Y, Yamashita H, Sawamoto N, Fujimoto R, Nishino I, Urushitani M, Mimori T, Takahashi R. Thigh muscle MRI findings in myopathy associated with anti-mitochondrial antibody. Muscle Nerve. 2020 Jan;61(1):81-87. doi: 10.1002/mus.26731. Epub 2019 Nov 8. PMID: 31588577.

 

3.Yamaguchi Y, Ayaki T, Li F, Tsujimura A, Kamada M, Ito H, Maki T, Sawamoto N, Urushitani M, Takahashi R. Phosphorylated NF-κB subunit p65 aggregates in granulovacuolar degeneration and neurites in neurodegenerative diseases with tauopathy. Neurosci Lett. 2019 Jun 21;704:229-235. doi: 10.1016/j.neulet.2019.03.036. Epub 2019 Apr 1. PMID: 30946927.

 

4.Sato TR, Itokazu T, Osaki H, Ohtake M, Yamamoto T, Sohya K, Maki T, Sato TK. Interhemispherically dynamic representation of an eye movement-related activity in mouse frontal cortex. Elife. 2019 Nov 5;8:e50855. doi: 10.7554/eLife.50855. PMID: 31687930; PMCID: PMC6892611.

 

5.Kinoshita H, Maki T, Yasuda K, Kishida N, Sasaoka N, Takagi Y, Kakizuka A, Takahashi R. KUS121, a valosin-containing protein modulator, attenuates ischemic stroke via preventing ATP depletion. Sci Rep. 2019 Aug 8;9(1):11519. doi: 10.1038/s41598-019-47993-w. PMID: 31395936; PMCID: PMC6687885.

 

6.Yasuda K, Maki T, Saito S, Yamamoto Y, Kinoshita H, Choi YK, Arumugam TV, Lim YA, Chen CLH, Wong PT, Ihara M, Takahashi R. Effect of fingolimod on oligodendrocyte maturation under prolonged cerebral hypoperfusion. Brain Res. 2019 Oct 1;1720:146294. doi: 10.1016/j.brainres.2019.06.013. Epub 2019 Jun 12. PMID: 31201815.

 

7.Yasuda K, Maki T, Takata M, Kimura K, Takahashi T, Kanbayashi T, Murase N, Ohtani R, Takahashi R, Nakamura M. Bilateral oculomotor nerve palsy in a case of anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder. J Clin Neurosci. 2019 Aug;66:271-272. doi: 10.1016/j.jocn.2019.05.043. Epub 2019 Jun 6. PMID: 31178306.

 

8.Nakaoku Y, Saito S, Yamamoto Y, Maki T, Takahashi R, Ihara M. The Dipeptidyl Peptidase-4 Inhibitor Linagliptin Ameliorates High-fat Induced Cognitive Decline in Tauopathy Model Mice. Int J Mol Sci. 2019 May 23;20(10):2539. doi: 10.3390/ijms20102539. PMID: 31126115; PMCID: PMC6566831.

 

9.Kishida N, Maki T, Takagi Y, Yasuda K, Kinoshita H, Ayaki T, Noro T, Kinoshita Y, Ono Y, Kataoka H, Yoshida K, Lo EH, Arai K, Miyamoto S, Takahashi R. Role of Perivascular Oligodendrocyte Precursor Cells in Angiogenesis After Brain Ischemia. J Am Heart Assoc. 2019 May 7;8(9):e011824. doi: 10.1161/JAHA.118.011824. PMID: 31020902; PMCID: PMC6512138.

 

10.Shimada T, Shindo A, Matsuyama H, Yata K, Niwa A, Sasaki R, Ayaki T, Maki T, Wakita H, Tomimoto H. Chronic cerebral hypoperfusion upregulates leptin receptor expression in astrocytes and tau phosphorylation in tau transgenic mice. Neurosci Lett. 2019 Jun 21;704:133-140. doi: 10.1016/j.neulet.2019.04.009. Epub 2019 Apr 4. PMID: 30954605.

 

11.Yamaguchi Y, Ayaki T, Li F, Tsujimura A, Kamada M, Ito H, Maki T, Sawamoto N, Urushitani M, Takahashi R. Phosphorylated NF-κB subunit p65 aggregates in granulovacuolar degeneration and neurites in neurodegenerative diseases with tauopathy. Neurosci Lett. 2019 Jun 21;704:229-235. doi: 10.1016/j.neulet.2019.03.036. Epub 2019 Apr 1. PMID: 30946927.

 

12.Hermanto Y, Maki T, Takagi Y, Miyamoto S, Takahashi J. Xeno-free culture for generation of forebrain oligodendrocyte precursor cells from human pluripotent stem cells. J Neurosci Res. 2019 Jul;97(7):828-845. doi: 10.1002/jnr.24413. Epub 2019 Mar 20. PMID: 30891830.

 

13.Egawa N, Shindo A, Hikawa R, Kinoshita H, Liang AC, Itoh K, Lok J, Maki T, Takahashi R, Lo EH, Arai K. Differential roles of epigenetic regulators in the survival and differentiation of oligodendrocyte precursor cells. Glia. 2019 Apr;67(4):718-728. doi: 10.1002/glia.23567. Epub 2018 Nov 28. PMID: 30793389; PMCID: PMC6573028.

 

14.Kinoshita H, Ayaki T, Maki T, Goda N, Yoshizawa A, Takahashi R. Non-aneurysmal Subarachnoid Hemorrhaging: A Rare Cause of Death in a Patient with Multiple System Atrophy. Intern Med. 2019 Jun 1;58(11):1643-1644. doi: 10.2169/internalmedicine.1567-18. Epub 2019 Feb 1. PMID: 30713290; PMCID: PMC6599920.

 

15.Imamura K, Izumi Y, Banno H, Uozumi R, Morita S, Egawa N, Ayaki T, Nagai M, Nishiyama K, Watanabe Y, Hanajima R, Oki R, Fujita K, Takahashi N, Ikeda T, Shimizu A, Morinaga A, Hirohashi T, Fujii Y, Takahashi R, Inoue H. Induced pluripotent stem cell-based Drug Repurposing for Amyotrophic lateral sclerosis Medicine (iDReAM) study: protocol for a phase I dose escalation study of bosutinib for amyotrophic lateral sclerosis patients. BMJ Open. 2019 Dec 2;9(12):e033131. doi: 10.1136/bmjopen-2019-033131. PMID: 31796494; PMCID: PMC7003406.

 

16.Yasuda K, Ayaki T, Kawabata Y, Murase N, Ohtani R, Nakamura M. [An autopsy case after endovascular thrombectomy for cardioembolic stroke due to nonbacterial thrombotic endocarditis]. Rinsho Shinkeigaku. 2019 Apr 25;59(4):195-199. Japanese. doi: 10.5692/clinicalneurol.cn-001252. Epub 2019 Mar 30. PMID: 30930366.

 

17.Nakayama Y, Sakamoto S, Tsuji K, Ayaki T, Tokunaga F, Ito H. Identification of linear polyubiquitin chain immunoreactivity in tau pathology of Alzheimer’s disease. Neurosci Lett. 2019 Jun 11;703:53-57. doi: 10.1016/j.neulet.2019.03.017. Epub 2019 Mar 15. PMID: 30885635.

 

18.Nagano M, Ayaki T, Koita N, Kitano T, Nishikori M, Goda N, Minamiguchi S, Ikeda A, Takaori-Kondo A, Takahashi R. Recurrent Epstein-Barr Virus-positive (EBV+) Primary Central Nervous System Lymphoma (PCNSL) in a Patient with Clinical Features of Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS). Intern Med. 2019;58(6):849-854. doi: 10.2169/internalmedicine.1246-18. Epub 2019 Mar 15. PMID: 30880301; PMCID: PMC6465023.

 

【2018年】

1.Li F, Ayaki T, Maki T, Sawamoto N, Takahashi R. NLRP3 Inflammasome-Related Proteins Are Upregulated in the Putamen of Patients With Multiple System Atrophy. J Neuropathol Exp Neurol. 2018 Nov 1;77(11):1055-1065. doi: 10.1093/jnen/nly090. PMID: 30295793.

 

2.Hikiami R, Yamakado H, Tatsumi S, Ayaki T, Hashi Y, Yamashita H, Sawamoto N, Tsuji T, Urushitani M, Takahashi R. Amyotrophic Lateral Sclerosis after Receiving the Human Papilloma Virus Vaccine: A Case Report of a 15-year-old Girl. Intern Med. 2018 Jul 1;57(13):1917-1919. doi: 10.2169/internalmedicine.0285-17. Epub 2018 Feb 9. PMID: 29434138; PMCID: PMC6064690.

 

3.Sakai M, Ueda S, Daito T, Asada-Utsugi M, Komatsu Y, Kinoshita A, Maki T, Kuzuya A, Takahashi R, Makino A, Tomonaga K. Degradation of amyloid β peptide by neprilysin expressed from Borna disease virus vector. Microbiol Immunol. 2018 May 17. doi: 10.1111/1348-0421.12602. Epub ahead of print. PMID: 29771464.

 

4.Kaji S, Maki T, Kinoshita H, Uemura N, Ayaki T, Kawamoto Y, Furuta T, Urushitani M, Hasegawa M, Kinoshita Y, Ono Y, Mao X, Quach TH, Iwai K, Dawson VL, Dawson TM, Takahashi R. Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy. Stem Cell Reports. 2018 Feb 13;10(2):356-365. doi: 10.1016/j.stemcr.2017.12.001. Epub 2018 Jan 11. PMID: 29337114; PMCID: PMC5830961.

 

5.Maki T, Choi YK, Miyamoto N, Shindo A, Liang AC, Ahn BJ, Mandeville ET, Kaji S, Itoh K, Seo JH, Gelman IH, Lok J, Takahashi R, Kim KW, Lo EH, Arai K. A-Kinase Anchor Protein 12 Is Required for Oligodendrocyte Differentiation in Adult White Matter. Stem Cells. 2018 May;36(5):751-760. doi: 10.1002/stem.2771. Epub 2018 Jan 22. PMID: 29314444; PMCID: PMC5918158.

 

6.Li F, Takechi H, Saito R, Ayaki T, Kokuryu A, Kuzuya A, Takahashi R. A comparative study: visual rating scores and the voxel-based specific regional analysis system for Alzheimer’s disease on magnetic resonance imaging among subjects with Alzheimer’s disease, mild cognitive impairment, and normal cognition. Psychogeriatrics. 2019 Mar;19(2):95-104. doi: 10.1111/psyg.12370. Epub 2018 Oct 1. PMID: 30276926.

 

7.Tamaki Y, Shodai A, Morimura T, Hikiami R, Minamiyama S, Ayaki T, Tooyama I, Furukawa Y, Takahashi R, Urushitani M. Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals. Sci Rep. 2018 Apr 16;8(1):6030. doi: 10.1038/s41598-018-24463-3. PMID: 29662239; PMCID: PMC5902603.

 

8.Ayaki T, Ito H, Komure O, Kamada M, Nakamura M, Wate R, Kusaka H, Yamaguchi Y, Li F, Kawakami H, Urushitani M, Takahashi R. Multiple Proteinopathies in Familial ALS Cases With Optineurin Mutations. J Neuropathol Exp Neurol. 2018 Feb 1;77(2):128-138. doi: 10.1093/jnen/nlx109. PMID: 29272468.

 

【2017年】

1.Matsuo K, Shindo A, Niwa A, Tabei KI, Akatsu H, Hashizume Y, Akiyama H, Ayaki T, Maki T, Sawamoto N, Takahashi R, Oikawa S, Tomimoto H. Complement Activation in Capillary Cerebral Amyloid Angiopathy. Dement Geriatr Cogn Disord. 2017;44(5-6):343-353. doi: 10.1159/000486091. Epub 2018 Feb 8. PMID: 29421784.

 

2.Hikiami R, Yamashita H, Koita N, Jingami N, Sawamoto N, Furukawa K, Kawai H, Terashima T, Oka N, Hashiguchi A, Takashima H, Urushitani M, Takahashi R. Charcot-Marie-Tooth disease type 2A with an autosomal-recessive inheritance: the first report of an adult-onset disease. J Hum Genet. 2018 Jan;63(1):89-92. doi: 10.1038/s10038-017-0353-3. Epub 2017 Nov 13. PMID: 29215088.

 

3.Takaya S, Sawamoto N, Okada T, Okubo G, Nishida S, Togashi K, Fukuyama H, Takahashi R. Differential diagnosis of parkinsonian syndromes using dopamine transporter and perfusion SPECT. Parkinsonism Relat Disord. 2018 Feb;47:15-21. doi: 10.1016/j.parkreldis.2017.11.333. Epub 2017 Nov 14. PMID: 29157745.

 

4.Saito N, Takahata K, Yamakado H, Sawamoto N, Saito S, Takahashi R, Murai T, Takahashi H. Altered awareness of action in Parkinson’s disease: evaluations by explicit and implicit measures. Sci Rep. 2017 Aug 14;7(1):8019. doi: 10.1038/s41598-017-08482-0. PMID: 28808252; PMCID: PMC5556120.

 

5.Kinoshita H, Maki T, Hata M, Nakayama Y, Yamashita H, Sawamoto N, Ikeda A, Takahashi R. Convergence paralysis caused by a localized cerebral infarction affecting the white matter underlying the right frontal eye field. J Neurol Sci. 2017 Apr 15;375:94-96. doi: 10.1016/j.jns.2017.01.054. Epub 2017 Jan 18. PMID: 28320198.

 

6.Yamao Y, Suzuki K, Kunieda T, Matsumoto R, Arakawa Y, Nakae T, Nishida S, Inano R, Shibata S, Shimotake A, Kikuchi T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S. Clinical impact of intraoperative CCEP monitoring in evaluating the dorsal language white matter pathway. Hum Brain Mapp. 2017 Apr;38(4):1977-1991. doi: 10.1002/hbm.23498. Epub 2017 Jan 23. PMID: 28112455; PMCID: PMC6866855.

 

7.Hermanto Y, Sunohara T, Faried A, Takagi Y, Takahashi J, Maki T, Miyamoto S. Transplantation of feeder-free human induced pluripotent stem cell-derived cortical neuron progenitors in adult male Wistar rats with focal brain ischemia. J Neurosci Res. 2018 May;96(5):863-874. doi: 10.1002/jnr.24197. Epub 2017 Nov 7. PMID: 29110329.

 

8.Uemura MT, Ihara M, Maki T, Nakagomi T, Kaji S, Uemura K, Matsuyama T, Kalaria RN, Kinoshita A, Takahashi R. Pericyte-derived bone morphogenetic protein 4 underlies white matter damage after chronic hypoperfusion. Brain Pathol. 2018 Jul;28(4):521-535. doi: 10.1111/bpa.12523. Epub 2017 May 31. PMID: 28470822; PMCID: PMC6099372.

 

9.Egawa N, Shindo A, Liang AC, Du Y, Xing C, Lo EK, Itoh K, Kinoshita H, Maki T, Takahashi R, Sudo R, Spector M, Lok J, Arai K. A Novel Three-Dimensional Culture System for Oligodendrocyte Precursor Cells. Stem Cells Dev. 2017 Jul 15;26(14):1078-1085. doi: 10.1089/scd.2016.0306. Epub 2017 May 24. PMID: 28446066; PMCID: PMC5512301.

 

10.Saito S, Yamamoto Y, Maki T, Hattori Y, Ito H, Mizuno K, Harada-Shiba M, Kalaria RN, Fukushima M, Takahashi R, Ihara M. Taxifolin inhibits amyloid-β oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy. Acta Neuropathol Commun. 2017 Apr 4;5(1):26. doi: 10.1186/s40478-017-0429-5. PMID: 28376923; PMCID: PMC5379578.

 

11.Hasegawa M, Majima K, Itokazu T, Maki T, Albrecht UR, Castner N, Izumo M, Sohya K, Sato TK, Kamitani Y, Sato TR. Selective Suppression of Local Circuits during Movement Preparation in the Mouse Motor Cortex. Cell Rep. 2017 Mar 14;18(11):2676-2686. doi: 10.1016/j.celrep.2017.02.043. PMID: 28297671.

 

12.Honjo Y, Ayaki T, Horibe T, Ito H, Takahashi R, Kawakami K. FKBP12-immunopositive inclusions in patients with α-synucleinopathies. Brain Res. 2018 Feb 1;1680:39-45. doi: 10.1016/j.brainres.2017.12.012. Epub 2017 Dec 12. PMID: 29246765.

 

13.Honjo Y, Ayaki T, Tomiyama T, Horibe T, Ito H, Mori H, Takahashi R, Kawakami K. Decreased levels of PDI and P5 in oligodendrocytes in Alzheimer’s disease. Neuropathology. 2017 Dec;37(6):495-501. doi: 10.1111/neup.12395. Epub 2017 Jul 21. PMID: 28731225.

 

14.Imamura K, Izumi Y, Watanabe A, Tsukita K, Woltjen K, Yamamoto T, Hotta A, Kondo T, Kitaoka S, Ohta A, Tanaka A, Watanabe D, Morita M, Takuma H, Tamaoka A, Kunath T, Wray S, Furuya H, Era T, Makioka K, Okamoto K, Fujisawa T, Nishitoh H, Homma K, Ichijo H, Julien JP, Obata N, Hosokawa M, Akiyama H, Kaneko S, Ayaki T, Ito H, Kaji R, Takahashi R, Yamanaka S, Inoue H. The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis. Sci Transl Med. 2017 May 24;9(391):eaaf3962. doi: 10.1126/scitranslmed.aaf3962. PMID: 28539470.

 

【2016年】

1.Uneno Y, Yokoyama A, Nishikawa Y, Funakoshi T, Ozaki Y, Aoyama I, Baba K, Yamaguchi D, Morita S, Mori Y, Kanai M, Kinoshita H, Inoue T, Sawamoto N, Matsumoto R, Matsumoto S, Muto M. Paraneoplastic Limbic Encephalitis in a Human Epidermal Growth Factor Receptor-2-positive Gastric Cancer Patient Treated with Trastuzumab-combined Chemotherapy: A Case Report and Literature Review. Intern Med. 2016;55(18):2605-9. doi: 10.2169/internalmedicine.55.6917. Epub 2016 Sep 15. PMID: 27629954.

 

2.Ishii T, Sawamoto N, Tabu H, Kawashima H, Okada T, Togashi K, Takahashi R, Fukuyama H. Altered striatal circuits underlie characteristic personality traits in Parkinson’s disease. J Neurol. 2016 Sep;263(9):1828-39. doi: 10.1007/s00415-016-8206-0. Epub 2016 Jun 22. PMID: 27334907.

 

3.Usami K, Matsumoto R, Sawamoto N, Murakami H, Inouchi M, Fumuro T, Shimotake A, Kato T, Mima T, Shirozu H, Masuda H, Fukuyama H, Takahashi R, Kameyama S, Ikeda A. Epileptic network of hypothalamic hamartoma: An EEG-fMRI study. Epilepsy Res. 2016 Sep;125:1-9. doi: 10.1016/j.eplepsyres.2016.05.011. Epub 2016 May 28. PMID: 27295078.

 

4.Kinoshita H, Yamakado H, Kitano T, Kitamura A, Yamashita H, Miyamoto M, Hitomi T, Okada T, Nakamoto Y, Sawamoto N, Takaori-Kondo A, Takahashi R. Diagnostic utility of FDG-PET in neurolymphomatosis: report of five cases. J Neurol. 2016 Sep;263(9):1719-26. doi: 10.1007/s00415-016-8190-4. Epub 2016 Jun 10. PMID: 27286845.

 

5.Imamura H, Matsumoto R, Takaya S, Nakagawa T, Shimotake A, Kikuchi T, Sawamoto N, Kunieda T, Mikuni N, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A. Network specific change in white matter integrity in mesial temporal lobe epilepsy. Epilepsy Res. 2016 Feb;120:65-72. doi: 10.1016/j.eplepsyres.2015.12.003. Epub 2015 Dec 10. PMID: 26735187.

 

6.Saito S, Kojima S, Oishi N, Kakuta R, Maki T, Yasuno F, Nagatsuka K, Yamamoto H, Fukuyama H, Fukushima M, Ihara M. A multicenter, randomized, placebo-controlled trial for cilostazol in patients with mild cognitive impairment: The COMCID study protocol. Alzheimers Dement (N Y). 2016 Oct 27;2(4):250-257. doi: 10.1016/j.trci.2016.10.001. PMID: 29067312; PMCID:

PMC5651350.

 

7.Hattori Y, Maki T, Saito S, Yamamoto Y, Nagatsuka K, Ihara M. Influence of Low-Dose Aspirin on Cerebral Amyloid Angiopathy in Mice. J Alzheimers Dis. 2016 Apr 12;52(3):1037-45. doi: 10.3233/JAD-160013. PMID: 27079719.

 

8.Uchida T, Tamaki Y, Ayaki T, Shodai A, Kaji S, Morimura T, Banno Y, Nishitsuji K, Sakashita N, Maki T, Yamashita H, Ito H, Takahashi R, Urushitani M. CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS. Sci Rep. 2016 Jan 11;6:19118. doi: 10.1038/srep19118. PMID: 26751167; PMCID: PMC4707540.

 

9.Kitamura A, Saito S, Maki T, Oishi N, Ayaki T, Hattori Y, Yamamoto Y, Urushitani M, Kalaria RN, Fukuyama H, Horsburgh K, Takahashi R, Ihara M. Gradual cerebral hypoperfusion in spontaneously hypertensive rats induces slowly evolving white matter abnormalities and impairs working memory. J Cereb Blood Flow Metab. 2016 Sep;36(9):1592-602. doi: 10.1177/0271678X15606717. Epub 2015 Oct 13. PMID: 26661170; PMCID: PMC5012514.

 

10.Kondo T, Funayama M, Miyake M, Tsukita K, Era T, Osaka H, Ayaki T, Takahashi R, Inoue H. Erratum to: Modeling Alexander disease with patient iPSCs reveals cellular and molecular pathology of astrocytes. Acta Neuropathol Commun. 2016 Sep 16;4(1):101. doi: 10.1186/s40478-016-0366-8. Erratum for: Acta Neuropathol Commun. 2016 Jul 11;4(1):69. doi: 10.1186/s40478-016-0337-0. PMID: 27638001; PMCID: PMC5026774.

 

11.Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, Ito H, Nureki O, Tokunaga F. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat Commun. 2016 Aug 24;7:12547. doi: 10.1038/ncomms12547. PMID: 27552911; PMCID: PMC4999505.

 

12.Kondo T, Funayama M, Miyake M, Tsukita K, Era T, Osaka H, Ayaki T, Takahashi R, Inoue H. Modeling Alexander disease with patient iPSCs reveals cellular and molecular pathology of astrocytes. Acta Neuropathol Commun. 2016 Jul 11;4(1):69. doi: 10.1186/s40478-016-0337-0. Erratum in: Acta Neuropathol Commun. 2016;4(1):101. PMID: 27402089; PMCID: PMC4940830.

 

13.Kawamoto Y, Ayaki T, Urushitani M, Ito H, Takahashi R. Activated caspase-9 immunoreactivity in glial and neuronal cytoplasmic inclusions in multiple system atrophy. Neurosci Lett. 2016 Aug 15;628:207-12. doi: 10.1016/j.neulet.2016.06.036. Epub 2016 Jun 21. PMID: 27345387.

 

【2015年】
1. Nakamae S, Kobatake Y, Suzuki R., Tsukui T, Kato S, Yamato O, Sakai H, Urushitani M, Maeda S, and Kamishina H. Accumulation and aggregate formation of mutant superoxide dismutase 1 in canine degenerative myelopathy. Neuroscience 2015 in press.

2. Nagano S, Takahashi Y, Yamamoto K, Masutani H, Fujiwara N, Urushitani M, Araki T. A cysteine residue affects the conformational state and neuronal toxicity of mutant SOD1 in mice – Relevance to the pathogenesis of ALS. Hum Mol Genet. 15;24(12): 3427-39, 2015.

3. Ando T, Omasa M, Kondo T, Yamada T, Sato M, Menju T, Aoyama A, Sato T, Chen F, Sonobe M, Date H. Predictive factors of myasthenic crisis after extended thymectomy for patients with myasthenia gravis. Eur J Cardiothorac Surg. 2015 Jan 24. pii: ezu530. [Epub ahead of print]

4. Fumuro T, Matsumoto R, Shimotake A, Matsuhashi M, Inouchi M, Urayama S, Sawamoto N, Fukuyama H, Takahashi R, Ikeda A. Network hyperexcitability in a patient with partial reading epilepsy:converging evidence from magnetoencephalography, diffusion tractography, and functional magnetic resonance imaging. Clin Neurophysiol, 126:675-81, 2015.

5. Koganemaru S, Sawamoto N, Aso T, Sagara A, Ikkaku T, Shimada K, Kanematsu M, Takahashi R, Domen K, Fukuyama H, Mima T. Task-specific brain reorganization in motor recovery induced by a hybrid-rehabilitation combining training with brain stimulation after stroke. Neurosci Res, 92:29-38, 2015.

6. Ashizuka A, Mima T, Sawamoto N, Aso T, Oishi N, Sugihara G, Kawada R, Takahashi H, Murai T, Fukuyama H.Functional relevance of the precuneus in verbal politeness. Neurosci Res, 91:48-56, 2015.

7. Esposito E, Hayakawa K, Maki T, Arai K, Lo EH. Effects of postconditioning on neurogenesis and angiogenesis during the recovery phase after focal cerebral ischemia. Stroke 2015 in press.

8. Maki T, Takahashi Y, Miyamoto N, Liang AC, Ihara M, Lo EH, Arai K. Adrenomedullin promotes differentiation of oligodendrocyte precursor cells into myelin-basic-protein expressing oligodendrocyte under pathological conditions in vitro. Stem Cell Research, 15:68-74, 2015.

9. Maki T, Maeda M, Uemura M, Lo EK, Terasaki Y, Liang AC, Shindo A, Choi YK, Taguchi A, Matsuyama T, Takahashi R, Ihara M, Arai K. Potential interactions between pericytes and oligodendrocyte precursor cells in perivascular regions of cerebral white matter. Neurosci Lett, 597:164-9, 2015.

10. Lok J, Wang X, Xiang C, Maki T, Wu L, Guo S, Noviski N, Arai K, Whalen MJ, Lo EH, Wang X. Targeting the neurovascular unit in brain trauma. CNS neuroscience & therapeutics, 21:304-308, 2015.

11. Itoh K, Maki T, Lok J, Arai K. Mechanisms of cell-cell interaction in oligodendrogenesis and remyelination after stroke. Brain research 2015 [Epub ahead of print].

12. Shindo A, Liang AC, Maki T, Miyamoto N, Tomimoto H, Lo EH, Arai K. Subcortical ischemic vascular disease: roles of oligodendrocyte function in experimental models of subcortical white matter injury. J Cereb Blood Flow Metab. 2015 [Epub ahead of print].

13. Saito S, Yamamoto Y, Ihara M. Mild cognitive impairment: at the crossroad of neurodegeneration and vascular dysfunction. Current Alzheimer Research 2015 in press.

14. Hattori Y, Enmi J, Kitamura A, Yamamoto Y, Saito S, Takahashi Y, Iguchi S, Tsuji M, Yamahara K, Nagatsuka K, Iida H, Ihara M. A Novel Mouse Model of Subcortical Infarcts with Dementia J Neurosci. 35: 3915-3928, 2015.

【2014年】
1. Oono M, Okado-Matsumoto A, Shodai A,Ido A, Ohta Y, Abe K, Ayaki T, Ito H, Takahashi R, Taniguchi N, Urushitani M. Transglutaminase 2 accelerates neuroinflammation in amyotrophic lateral sclerosis through interaction with misfolded superoxide dismutase 1. J Neurochem, 128: 403-418, 2014.

2. Morimura T, Numata Y, Nakamura S, Hirano E, Gotoh L, Goto YI, Urushitani M, Inoue K. Attenuation of endoplasmic reticulum stress in Pelizaeus-Merzbacher disease by an anti-malaria drug, chloroquine. Exp Biol Med, 239: 489-501, 2014.

3. Kitajima Y, Tashiro Y, Suzuki N, Warita H, Kato M, Tateyama M, Ando R, Izumi R, Yamazaki M, Abe M, Sakimura K, Ito H, Urushitani M, Nagatomi R, Takahashi R, and Aoki M. Proteasome dysfunction induces muscle growth defects and protein aggregation. J Cell Sci, 127:5204-5217, 2014.

4. Ayaki T, Ito H, Fukushima H, Inoue T, Kondo T, Ikemoto A, Asano T, Shodai A, Fujita T, Fukui S, Morino H, Nakano S, Kusaka H, Yamashita H, Ihara M, Matsumoto R, Kawamata J, Urushitani M, Kawakami H, Takahashi R. Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant. Acta Neuropathologica Comm. 2:172, 2014.

5. Watanabe M, Kondo T, Murakata K, Kageyama T, Shibata Y, Takahashi T, Nomura K, Matsumoto S. Antibodies to neural and non-neural autoantigens in Japanese patients with CNS demyelinating disorders. Journal of Neuroimmunology, 274: 155-160, 2014.

6. Sasamoto A, Miyata J, Kubota M, Hirao K, Kawada R, Fujimoto S, Tanaka Y, Hazama M, Sugihara G, Sawamoto N, Fukuyama H, Takahashi H, Murai T. Global Association Between Cortical Thinning and White Matter Integrity Reduction in Schizophrenia. Schizophr Bull, 40(2): 420-7, 2014.

7. Yamao Y, Matsumoto R, Kunieda T, Arakawa Y, Kobayashi K, Usami K, Shibata S, Kikuchi T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S. Intraoperative dorsal language network mapping by using single-pulse electrical stimulation. Hum Brain Mapp, 35(9): 4345-61, 2014.

8. Yoshida M, Origuchi M, Urayama S, Takatsuki A, Kan S, Aso T, Shiose T, Sawamoto N, Miyauchi S, Fukuyama H, Seiyama A. fMRI evidence of improved visual function in patients with progressive retinitis pigmentosa by eye-movement training. Neuroimage Clin, 5: 161-8, 2014.

9. Tsurumi K, Kawada R, Yokoyama N, Sugihara G, Sawamoto N, Aso T, Fukuyama H, Murai T, Takahashi H. Insular activation during reward anticipation reflects duration of illness in abstinent pathological gamblers. Front Psychol, 5:1013, 2014.

10. Koelkebeck K, Miyata J, Kubota M, Kohl W, Son S, Fukuyama H, Sawamoto N, Takahashi H, Murai T. The contribution of cortical thickness and surface area to gray matter asymmetries in the healthy human brain. Hum Brain Mapp, 35: 6011-22, 2014.

11. Yang J, Yu Y, Kunita A, Huang Q, Wu J, Sawamoto N, Fukuyama H. Tactile priming modulates the activation of the fronto-parietal circuit during tactile angle match and non-match processing: an fMRI study. Front Hum Neurosci, 8:926, 2014.

12. Hattori Y, Kitamura A, Nagatsuka K, Ihara M. A novel mouse model of ischemic carotid artery disease. PLoS One, 18: 9(6) e100257, 2014. 13. Hattori Y, Kitamura A, Tsuji M, Nagatsuka K, Ihara M. Motor and cognitive impairment in a mouse model of ischemic carotid artery disease. Neurosci Lett, 12: 581C 1-6, 2014.

14. Ayaki T, Ito H, Fukushima H, Inoue T, Kondo T, Ikemoto A, Asano T, Shodai A, Fujita T, Fukui S, Morino H, Nakano S, Kusaka H, Yamashita H, Ihara M, Matsumoto R, Kawamata J, Urushitani M, Kawakami H, Takahashi R. Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant. Acta Neuropathol Commun, 2:172, 2014.

15. Hattori Y, Okamoto Y, Maki T, Yamamoto Y, Oishi N, Yamahara K, Nagatsuka K, Takahashi R, Kalaria RN, Fukuyama H, Kinoshita M, Ihara M. Silent information regulator 2 homolog 1 counters cerebral hypoperfusion injury by deacetylating endothelial nitric oxide synthase. Stroke 2014;45:3403-3411.

16. Takahashi Y, Maki T, Liang AC, Itoh K, Lok J, Osumi N, Arai K. p38 MAP kinase mediates transforming-growth factor-β1-induced upregulation of matrix metalloproteinase-9 but not-2 in human brain pericytes. Brain research 2014;1593:1-8.

17. Maki T*, Seo JH*, Maeda M, Miyamoto N, Liang AC, Hayakawa K, Pham LDD, Suwa F, Taguchi A, Matsuyama T, Ihara M, Kim KW, Lo EH, Arai K. Oligodendrocyte precursor cells support blood-brain barrier integrity via TGF-β signaling. PLoS One 2014;9:e103174. (*These two authors equally contributed to this work)

18. Maki T, Okamoto Y, Carare RO, Hase Y, Hattori Y, Hawkes CA, Saito S, Yamamoto Y, Terasaki Y, Ishibashi-Ueda H, Taguchi A, Takahashi R, Miyakawa T, Kalaria RN, Lo EH, Arai K, Ihara M. Phosphodiesterase III inhibitor maintains amyloid β drainage and hemodynamic reserve in cerebrovascular β-amyloidosis. Annals of Clinical and Translational Neurology 2014;1:519-533.

19. Miyamoto N, Pham LDD, Maki T, Liang AC, Arai K. A radical scavenger edaravone inhibits matrix metalloproteinase-9 upregulation and blood-brain barrier breakdown. Neurosci Lett. 573: 40-45, 2014.

20. Ihara M, Taguchi A, Maki T, Washida K, Tomimoto H. A mouse model of chronic cerebral hypoperfusion characterizing features of vascular cognitive impairment. Methods in Molecular Biology, 1135: 95-102, 2014.

21. Saito S, and Ihara M. New therapeutic approaches for Alzheimer’s disease and cerebral amyloid angiopathy. Front. Aging Neurosci. 6: 290, 2014.

22. Maki T, Okamoto Y, Carare R. O, Hase Y, Hattori Y, Hawkes C. A, Saito S, Yamamoto Y, Terasaki Y, Ishibashi-Ueda, H, Taguchi A, Takahashi R, Miyakawa T, Kalaria R. N, Lo E. H, Arai K and Ihara M. Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloid. Annals of Clinical and Translational Neurology. 1: 519－533, 2014.

23. Nakaoku Y, Ihara M, Hase Y, Okamoto Y, Saito S,　Hishizawa M, Uemura K, Kuwahara M, Oka N, Kusunoki S, Takahashi R. Possible paraneoplastic etiology in a case of Guillain－Barre´ syndrome with tumoral expression of ganglioside GM3. Neurology & Clinical Neurosc. 2: 169－171, 2014. Ihara M, Nishino M, Taguchi A, Yamamoto Y, Hattori Y, Saito S, Takahashi Y, Tsuji M, Kasahara Y, Takata Y, Okada M. Cilostazol add-on therapy in patients with mild dementia receiving donepezil: a retrospective study. PLoS One.9(2): e89516, 2014.

【2013年】
1. Shodai A, Morimura T, Ido A, Uchida T, Ayaki T, Takahashi R, Kitazawa S, Suzuki S, Shirouzu M, Kigawa T, Muto Y, Yokoyama S, Takahashi R, Kitahara R, Ito H, Fujiwara. Aberrant assembly of RNA-recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein-43 (TDP-43). J Biol Chem, 288, 21: 14886-14905, 2013.

2. Kageyama T, Komori M, Miyamoto K, Ozaki A, Suenaga T, Takahashi R, Kusunoki S, Matsumoto S, Kondo T. Combination of cyclosporine A with corticosteroids is effective for the treatment of neuromyelitis optica. Journal of Neurology, 260: 627-634, 2013.

3. Kubota M, Miyata J, Sasamoto A, Sugihara G, Yoshida H, Kawada R, Fujimoto S, Tanaka Y, Sawamoto N, Fukuyama H, Takahashi H, Murai T. Thalamocortical disconnection in the orbitofrontal region associated with cortical thinning in schizophrenia. JAMA Psychiatry, 70(1): 12-21, 2013.

4. Ubukata S, Miyata J, Yoshizumi M, Uwatoko T, Hirao K, Fujiwara H, Kawada R, Fujimoto S, Tanaka Y, Kubota M, Sasamoto A, Sawamoto N, Fukuyama H, Takahashi H, Murai T. Regional gray matter reduction correlates with subjective quality of life in schizophrenia. J Psychiatr Res, 47(4): 548-54, 2013.

5. Mitsueda-Ono T, Ikeda A, Sawamoto N, Aso T, Hanakawa T, Kinoshita M, Matsumoto R, Mikuni N, Amano S, Fukuyama H, Takahashi R. Internal structural changes in the hippocampus observed on 3-Tesla MRI in patients with mesial temporal lobe epilepsy. Intern Med, 52(8): 877-85, 2013.

6. Koelkebeck K, Hirao K, Miyata J, Kawada R, Saze T, Dannlowski U, Ubukata S, Ohrmann P, Bauer J, Pedersen A, Fukuyama H, Sawamoto N, Takahashi H, Murai T. Impact of gray matter reductions on theory of mind abilities in patients with schizophrenia. Soc Neurosci, 8(6): 631-9, 20113.

7. Oguri T, Sawamoto N, Tabu H, Urayama S, Matsuhashi M, Matsukawa N, Ojika K, Fukuyama H. Overlapping connections within the motor cortico-basal ganglia circuit: fMRI-tractography analysis. Neuroimage, 78: 353-62, 2013.

8. Maki T, Liang AC, Miyamoto N, Lo EH, Arai K. Mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cells in white matter diseases. Frontiers in Cellular Neuroscience 2013;7:275.

9. Maki T, Hayakawa K, Pham LD, Xing C, Lo EH, Arai K. Biphasic mechanisms of neurovascular unit injury and protection in CNS diseases. CNS Neurol Disord Drug Targets. 2013;12:302-15. (highlighted paper)

10. Miyamoto N, Maki T, Pham LDD, Hayakawa K, Seo JH, Mandeville ET, Mandeville JB, Kim KW, Lo EH, Arai K. Oxidative stress interferes with white matter renewal after prolonged cerebral hypoperfusion in mice. Stroke 2013;44:3516-3521.

11. Seo JH, Miyamoto N, Hayakawa K, Pham LD, Maki T, Ayata C, Kim KW, Lo EH, Arai K. Oligodendrocyte precursors induce early blood-brain barrier opening after white matter injury. J Clin Invest. 2013;123:782-6.

【2012年】
1. Kubota M, Miyata J, Sasamoto A, Sugihara G, Yoshida H, Kawada R, Fujimoto S, Tanaka Y, Sawamoto N, Fukuyama H, Takahashi H, Murai T: Thalamocortical Disconnection in the Orbitofrontal Region Associated With Cortical Thinning in Schizophrenia. Arch Gen Psychiatry, in press.

2. Okuchi S, Okada T, Ihara M, Gotoh K, Kido A, Fujimoto K, Yamamoto A, Kanagaki M, Tanaka S, Takahashi R, Togashi K: Visualization of Lenticulostriate Arteries by Flow-Sensitive Black-Blood MR Angiography on a 1.5T MRI System: A Comparative Study between Subjects with and without Stroke. AJNR Am J Neuroradiol, in press.

3. Ihara M, Okamoto Y, Takahashi R: Suitability of the Montreal Cognitive Assessment versus the Mini-Mental State Examination in Detecting Vascular Cognitive Impairment. J Stroke Cerebrovasc Dis, in press.

4. Ihara M, Okamoto Y, Hase Y, Takahashi R: Association of Physical Activity with the Visuospatial/Executive Functions of the Montreal Cognitive Assessment in Patients with Vascular Cognitive Impairment. J Stroke Cerebrovasc Dis, in press.

5. Kubota M, Miyata J, Sasamoto A, Kawada R, Fujimoto S, Tanaka Y, Sawamoto N, Fukuyama H, Takahashi H, Murai T: Alexithymia and reduced white matter integrity in schizophrenia: a diffusion tensor imaging study on impaired emotional self-awareness. Schizophr Res, 141: 137-43, 2012.

6. Mihara M, Hara H, Hayashi Y, Narushima M, Yamamoto T, Todokoro T, Iida T, Sawamoto N, Araki J, Kikuchi K, Murai N, Okitsu T, Kisu I, Koshima I: Pathological steps of cancer-related lymphedema: histological changes in the collecting lymphatic vessels after lymphadenectomy. PLoS One, 7: e41126, 2012.

7. Aotani D, Ebihara K, Sawamoto N, Kusakabe T, Aizawa-Abe M, Kataoka S, Sakai T, Iogawa H, Ebihara C, Fujikura J, Hosoda K, Fukuyama H, Nakao K: Functional magnetic resonance imaging analysis of food-related brain activity in patients with lipodystrophy undergoing leptin replacement therapy. J Clin Endocrinol Metab, 97: 3663-71, 2012.

8. Matsuyoshi D, Ikeda T, Sawamoto N, Kakigi R, Fukuyama H, Osaka N: Differential roles for parietal and occipital cortices in visual working memory. PLoS One, 7: e38623, 2012.

9. Inoue M, Kojima Y, Mima T, Sawamoto N, Matsuhashi M, Fumuro T, Kinboshi M, Koganemaru S, Kanda M, Shibasaki H: Pathophysiology of unilateral asterixis due to thalamic lesion. Clin Neurophysiol, 123: 1858-64, 2012.

10. Otsuka Y, Yamauchi H, Sawamoto N, Iseki K, Tomimoto H, Fukuyama H: Diffuse tract damage in the hemispheric deep white matter may correlate with global cognitive impairment and callosal atrophy in patients with extensive leukoaraiosis. AJNR Am J Neuroradiol, 33: 726-32, 2012.

11. Miyata J, Sasamoto A, Koelkebeck K, Hirao K, Ueda K, Kawada R, Fujimoto S, Tanaka Y, Kubota M, Fukuyama H, Sawamoto N, Takahashi H, Murai T: Abnormal asymmetry of white matter integrity in schizophrenia revealed by voxelwise diffusion tensor imaging. Hum Brain Mapp, 33: 1741-9, 2012.

12. Tashiro Y, Urushitani M, Inoue H, Koike M, Uchiyama Y, Komatsu M, Tanaka K, Yamazaki M, Abe M, Misawa H, Sakimura K, Ito H, Takahashi R: Motor Neuron-specific Disruption of Proteasomes, but Not Autophagy, Replicates Amyotrophic Lateral Sclerosis. J Biol Chem, 287: 42984-94, 2012.

13. Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T, Okita K, Asaka I, Aoi T, Watanabe A, Yamada Y, Morizane A, Takahashi J, Ayaki T, Ito H, Yoshikawa K, Yamawaki S, Suzuki S, Watanabe D, Hioki H, Kaneko T, Makioka K, Okamoto K, Takuma H, Tamaoka A, Hasegawa K, Nonaka T, Hasegawa M, Kawata A, Yoshida M, Nakahata T, Takahashi R, Marchetto MC, Gage FH, Yamanaka S, Inoue H: Drug screening for ALS using patient-specific induced pluripotent stem cells. Sci Transl Med, 4: 145ra104, 2012.

14. Honjo Y, Ito H, Horibe T, Shimada H, Nakanishi A, Mori H, Takahashi R, Kawakami K: Derlin-1-immunopositive inclusions in patients with Alzheimer’s disease. Neuroreport, 23: 611-5, 2012.

15. Kawamoto Y, Ito H, Ihara M, Takahashi R: Immunohistochemical localization of X-linked inhibitor of apoptosis protein in brainstem-type and cortical Lewy bodies. Neuroreport, 23: 162-7, 2012.

16. Kasahara S, Miki Y, Kanagaki M, Kondo T, Yamamoto A, Morimoto E, Okada T, Ito H, Takahashi R, Togashi K. “Hot cross bun” sign in multiple system atrophy with predominant cerebellar ataxia: a comparison between proton density-weighted imaging and T2-weighted imaging. Eur J Radiol, 81: 2848-52, 2012.

17. Hase Y, Okamoto Y, Fujita Y, Kitamura A, Nakabayashi H, Ito H, Maki T, Washida K, Takahashi R, Ihara M. Cilostazol, a phosphodiesterase inhibitor, prevents no-reflow and hemorrhage in mice with focal cerebral ischemia. Exp Neurol, 233: 523-33, 2012.

18. Okamoto Y, Yamamoto T, Kalaria RN, Senzaki H, Maki T, Hase Y, Kitamura A, Washida K, Yamada M, Ito H, Tomimoto H, Takahashi R, Ihara M. Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts. Acta Neuropathol, 123: 381-94. 2012.

19. Kitamura A, Fujita Y, Oishi N, Kalaria RN, Washida K, Maki T, Okamoto Y, Hase Y, Yamada M, Takahashi J, Ito H, Tomimoto H, Fukuyama H, Takahashi R, Ihara M: Selective white matter abnormalities in a novel rat model of vascular dementia. Neurobiol Aging, 33: 1012.e25-35, 2012.

20. Fujita Y, Kuchimaru T, Kadonosono T, Tanaka S, Hase Y, Tomimoto H, Hiraoka M, Kizaka-Kondoh S, Ihara M, Takahashi R: In vivo imaging of brain ischemia using an oxygen-dependent degradative fusion protein probe. PLoS One, 7: e48051, 2012.

21. Watanabe H, Ono M, Kimura H, Matsumura K, Yoshimura M, Okamoto Y, Ihara M, Takahashi R, Saji H: Synthesis and biological evaluation of novel oxindole derivatives for imaging neurofibrillary tangles in Alzheimer’s disease. Bioorg Med Chem Lett, 22: 5700-3, 2012.

22. Cui M, Ono M, Kimura H, Ueda M, Nakamoto Y, Togashi K, Okamoto Y, Ihara M, Takahashi R, Liu B, Saji H: Novel (18)F-Labeled Benzoxazole Derivatives as Potential Positron Emission Tomography Probes for Imaging of Cerebral β-Amyloid Plaques in Alzheimer’s Disease. J Med Chem, 55: 9136-45, 2012.

23. Shimazu Y, Minakawa EN, Nishikori M, Ihara M, Hashi Y, Matsuyama H, Hishizawa M, Yoshida S, Kitano T, Kondo T, Ishikawa T, Takahashi R, Takaori-Kondo A. A case of follicular lymphoma associated with paraneoplastic cerebellar degeneration. Intern Med, 51: 1387-92, 2012.

24. Maesako M, Uemura K, Kubota M, Kuzuya A, Sasaki K, Asada M, Watanabe K, Hayashida N, Ihara M, Ito H, Shimohama S, Kihara T, Kinoshita A: Environmental enrichment ameliorated high fat diet-induced Aβ deposition and memory deficit in APP transgenic mice. Neurobiol Aging, 33: 1011.e11-23, 2012.

25. Komori M, Matsuyama Y, Nirasawa T, Thiele H, Becker M, Alexandrov T, Saida T, Tanaka M, Matsuo H, TomimotoH, Takahashi R, Tashiro K, Ikegawa M, Kondo T. Proteomic pattern analysis discriminates among multiple sclerosis-related disorders. Ann Neurol, 71: 614-23, 2012【2011年】
1. Maki T, Ihara M, Fujita Y, Nambu T, Miyashita K, Yamada M, Washida K, Nishio K, Ito H, Harada H, Yokoi H, Arai H, Itoh H, Nakao K, Takahashi R, Tomimoto H: Angiogenic and vasoprotective effects of adrenomedulin on prevention of cognitive decline after chronic cerebral hypoperfusion in mice. Stroke, 42: 1122-1128, 2011.

2. Yamada M, Ihara M, Okamoto Y, Maki T, Washida K, Kitamura A, Hase Y, Ito H, Takao K, Miyakawa T, Kalaria RN, Tomimoto H, Takahashi R: The influence of chronic cerebral hypoperfusion on cognitive function and amyloid b metabolism in APP overexpressing mice. PLoS One, 6: e16567, 2011.

3. Ito H, Fujita K, Nakamura M, Wate R, Kaneko S, Sasaki S, Yamane K, Suzuki N, Aoki M, Shibata N, Togashi S, Kawata A, Mochizuki Y, Mizutani T, Maruyama H, Hirano A, Takahashi R, Kawakami H, Kusaka H: Optineurin is co-localized with FUS in basophilic inclusions of ALS with FUS mutation and in basophilic inclusion body disease. Acta Neuropathol, 121: 555-557, 2011.

4. Maki T, Ihara M, Fujita Y, Nambu T, Harada H, Ito H, Nakao K, Tomimoto H, Takahashi R: Angiogenic roles of adrenomedullin through VEGF induction. Neuroreport, 22: 442-447, 2011.

5. Okamoto Y, Shirakashi Y, Ihara M, Urushitani M, Oono M, Kawamoto Y, Yamashita H, Shimohama S, Kato S, Hirano A, Tomimoto H, Ito H, Takahashi R: Colocalization of 14-3-3 proteins with SOD1 in Lewy Body-like hyaline inclusions in familial amyotrophic lateral sclerosis cases and the animal model. PLoS One, 6: e20427, 2011.

6. Honjo Y, Ito H, Horibe T, Takahashi R, Kawakami K: Protein disulfide isomerase immunopositive glial cytoplasmic inclusions in patients with multiple system atrophy. Int J Neurosci, 121: 543-50, 2011.

7. Maki T, Wakita H, Mase M, Itagaki I, Saito N, Ono F, Adachi K, Ito H, Takahashi R, Ihara M, Tomimoto H: Watershed Infarcts in a multiple microembolic model of monkey. Neurosci Lett, 499: 80-83, 2011.

8. Ito H, Nakamura M, Komure O, Ayaki T, Wate R, Maruyama H, Nakamura Y, Fujita K, Kaneko S, Okamoto Y, Ihara M, Konishi T, Ogasawara K, Hirano A, Kusaka H, Kaji R, Takahashi R, Kawakami H: Clinicopathologic study on an ALS family with a heterozygous E478G optineurin mutation. Acta Neuropathol, 122: 223-229, 2011.

9. Honjo Y, Kaneko S, Ito H, Horibe T, Takahashi R, Kawakami K: Protein disulfide isomerase immunopositive inclusions in patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler, 12: 444-450, 2011.

10. Saito S, Ozaki A, Takahashi M, Ito H, Matsumoto S, Tomimoto H: Clustering of multifocal cerebral infarctions in CADASIL: a case report. J Neurol, 258: 325-327, 2011.

11. Matsuya N, Komori M, Nomura K, Nakane S, Fukudome T, Goto H, Shiraishi H, Wandinger KP, Matsuo H, Kondo T. Increased T-cell immunity against aquaporin-4 and proteolipid protein in neuromyelitis optica. Int Immunol, 23: 565-573, 2011.

12. Okamoto Y, Ihara M, Urushitani M, Yamashita H, Kondo T, Tanigaki A, Oono M, Kawamata J, Ikemoto A, Kawamoto Y, Takahashi R, Ito H: An autopsy case of SOD1-related ALS with TDP-43-positive inclusions. Neurology, 77:1993-1995, 2011.